This card can give you incredible mileage in Jinteki: Replicating Perfection or Industrial Genomics: Growing Solutions.
Firstly it lets you stack advancement tokens, this means it can be a target for Space Camp and Trick of Light. Inside Weyland it can also benefit from Shipment from Kaguya, Hollywood Renovation or any of the other cheesy Weyland cards that allow/help you advance Ice.
Secondly it lets you use any subroutine, this is great because some of the best ice for these Jinteki decks are Excalibur or Susanoo-No-Mikoto which are both Uniques. Furthermore it can be used to fire net damage subroutines such as Neural Katana or trash a program routines from other Ice like Ichi 1.0, Grim or Swordsman. It also fills in a big gap in Jinteki ice - it can also let you end the run. Remember Wormhole lets you fire off strong subroutines that have the misfortune of sitting on low strength Ice or Ice that don't often get encountered, so don't forget Architect or Crick. An even weirder possibility is to use it to trash hardware by combining it with Taurus or using it to 'refire' failed traps like Whirlpool.
Another benefit of this ice compared to staples such as Komainu is that it is not vulnerable to Parasite.
With a full 3 advancement tokens on it (or even just 2) it is not particularly vulnerable to derez abilities such as Emergency Shutdown or Crescentus. Since the surprise factor will likely be low in any case you could also rez it early with Executive Boot Camp against DDoS/Blackmail style decks. It will cost Cyber-Cypher 4 to break, Gordian Blade or Eater 6 to break and Faust a whopping 4 cards as well. It will also stop Endless Hunger in its tracks, since it is not an ETR subroutine... even though you can use it to ETR. For added hilarity you can even land some borrowed brain damage from a lowly Viktor 1.0
Wormhole can be a Femme Fatale target, it can be broken for 1 counter with D4v1d and it can also be broken with Knight. Once you advance it, it will also be the first piece of ice that gets bounced by Leela Patel: Trained Pragmatist's ability.
The cost could also be considered a weakness, since it costs a combination of 9 or 3 advancement tokens to rez it. It's worth noting that it loses one of the big benefits of Ice by telegraphing itself as an advancable, although it can make up for it in flexibility.
Lastly Wormhole is completely worthless if you don't have any other Ice rezzed, so you will need to support it by playing other Ice with useful subroutines.
I don't recommend trying for this sort of thing but you could try and combine it with Inazuma, Sensei, Marker, TL;DR, Flare, Shinobi, Bullfrog or even Cell Portal. Marcus Batty is a more reasonable and realistically landable combo which can potentially do some damage as well.