Omega representing the last letter of the Greek alphabet bookends the theme started with Alpha (The first letter of the Greek Alphabet) allowing the runner to have an economical AI option on the last piece of ice on every server.
See the code behind everything: Rielle "Kit" Peddler: Transhuman transforms the first ice of every server into code-gate where decent decoders such as Gordian Blade or Torch can take on everything, then Omega can take care of the last. For deeper servers Paintbrush (at the cost of 1 time it is used) could potentially make any server protected by less than 5 layers of ice insecure! (even more if any middle ice happens to be code-gate anyway.) Escher could be used to rearrange things to suit the runner even more (move none-code gate ice to innermost layer for example to make the server more efficiently accessible in the future)
By-pass: Inside Job has quite a bit of synergy with Omega making it much more likely for the runner to actually reach that last piece of ice where Omega can do it's work. Similarly DDoS could potentially have the same effect on a server where outermost ice is unrezzed.
Install cheaply: At 7 to install such a limited AI might give pause, while Omega is most effective early game, Personal Workshop can bring the price down to potentially 0 if the runner is patient. London Library allows Omega to be installed free (temporarily) where it can then be trashed by the runner with Scavenge to cycle it on to the rig by sending it to the trash momentarily only to recur it thereafter, cost? 2 (not counting installation of London Library) net savings? 7 . (With a little less certainty Eureka! could possibly accomplish the same thing.) Alternatively Test Run with Scavenge could allow the runner to tutor for Omega first, total cost? 2s & 3
Keep server on thin ice: So long as key servers are thinly defended Omega can continue to be a reliable AI ice breaker. Forked, Knifed, Spooned & Parasite can certainly be used to remove layers of ice, additionally Forged Activation Orders, perhaps after Account Siphon or Emergency Shutdown to make the corp poor can also effectively remove yet more layers of ice.
(Did I miss something obvious, I'd appreciate suggestions in the comments below, I may add it to this review)
Early game access: With Omega out early, the corp faces the difficulty of having to create 2 layers of ice on each server (possibly both layers needing End the run's) before having any meaningful measure of security.
Cheaper ice-breaking: Particularly when facing sentry ice, Omega can provide a more cost effecting breaking compared to many killer sub-type ice breakers.
Anti-AI: Swordsman & Turing both represent hard counters to an AI-only ice breaker strategy. Since Omega has only 1 base strength, Wraparound or any other uber-high strength ice could be rather taxing or even potentially price a runner out of a server.
End-Game Particularly mid-to-end game the corp will be able to deepen protection on servers diminishing the runners ability to reach ice target-able by Omega
Cost: At 7, Omega's cost is right up there with other heavy-hitters which given it's limited scope could make that cost a bit more difficult to swallow.
Omega is one of the least popular AI ice breakers, still perhaps in combo with Rielle "Kit" Peddler: Transhuman & Paintbrush, ice-trashing programs etc it has a viable nieche that favors aggressive play-style.
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