Make sure to focus on getting your rig set up. A common rhythm for me in the mid-game is 2 clicks with Professional Contacts install Program or Hardware then play/install non Program or Hardware card. Modded to R&D Interface is an easy way to clear cards out of hand.
With the clot threat you can pick off agendas from remotes but be careful you don't forget about getting your rig up. I will often lose games if I don't get set up.
I use to run Astrolabe for my console but have switched to Mirror and I love it. Astrolabe makes MU a little challenging and it sucks to have to trash a Cloak to install a Self-modifying Code. Try and get Mirror out before you have MU problems. Eventually you will be able to get all your breakers and 3 Cloak. Mirror also has the replacement of a reoccurring credit effect which is a nice plus.
This is the best part of the game so have fun.
Pressure HQ with HQ Interface and deep digs on R&D with 3 R&D Interface and The Maker's Eye. As a side note when you get Mirror out I found people will put a ton of ice on R&D so the HQ pressure can help force them to put ice on HQ.