Two words: Data Mine.
Land all three and flip the Jinteki Biotech: Life Imagined brewery for larfs.
Any runner worth their stuff is gonna have some damage mitigation that you'll have to play around, such as I've Had Worse. But when their hand size is down to two, floating one of those around is gonna be mighty limiting. Deus X and Net Shield can't protect them from damage of the brain, much less the ensuing hurting of the butt.
Definitely not a tourney strat, but I'll be damned if it's not one for good times over the kitchen table or the hobby shop backroom. Just don't forget to splash in some cheap end the run ice (Or go full tax/click compression). What are you? A Jinteki nooblord?